jobid=A.0.056
Heterogeneity in control: analyzing how subpopulations of Purkinje cells join forces to control our movements
Functie inhoud
The Schonewille lab is looking for a PhD student to study how different subpopulations of neurons in the cerebellum individually contribute to the control of movement. This project is centered around behavior and electrophysiology in mice, expanded with optogenetic, anatomical, genetic and modeling approaches.
The cerebellum plays a crucial role in integrating the information from our senses with the movements we want to make. Central in this integration is the Purkinje cell, receiving enormous amounts of input with its massive dendritic tree. Recent developments indicate that the cerebellum contains subpopulations of Purkinje cells with distinct gene expression profiles.
The aim of this PhD project is to investigate how these subpopulations operate, individually and in cooperation, to control movements. To this end, the PhD candidate will primarily use in vivo electrophysiology, optogenetic stimulation and behavioral analysis, which can be combined with immunohistochemistry, anatomical tracing and ex vivo electrophysiology. The project is funded by a NWO Vici grant, so the PhD candidate will be part of a team of researchers and technicians working on the proposed project.
Werkomgeving
The Department of Neuroscience at Erasmus MC, Rotterdam is a dynamic and collaborative environment of about 130 employees and students, across 21 research groups (neuro.nl). As a department, we are embedded in a dynamic, internationally competitive research community. We collaborate with universities and institutes at a national and international level and host fruitful relationships with our industry partners.
The PhD candidate will work in the Schonewille lab, which focuses on the differentiation and development of cerebellar function and its role in sensorimotor integration (neuro.nl/research/schonewille). The lab aims to study cerebellar functioning in health and disease by linking cellular and population neuronal activity to behavior, combined with a range of molecular biological approaches. You will join an international team of researchers with a wide range of skills and backgrounds.
Profiel
We are looking for a highly-motivated candidate with good written and verbal communication skills that holds a MSc degree in Neuroscience or closely related field.
The candidate has experience with electrophysiological recordings and affinity for data analysis and coding. The candidate should be able to work both independently and as a member of a large multidisciplinary team. Finally, you should have good scientific writing and presentation skills in English.
Wat bieden wij
Beschrijf de belangrijkste arbeidsvoorwaarden die het voor de kandidaat aantrekkelijk maken. Gebruik bulletpoints om de aandacht te behouden. Vul onderstaande aan of verwijder wat niet van toepassing is.
- Een een tijdelijk contract voor 4 jaar.
- Een bruto maandsalaris tussen de € 3.108,- en € 3.939 ,- (schaal OIO ) bij een volledige werkweek van 36 uur.
- Een toeslag voor onregelmatige diensten.
- Je kunt fulltime of parttime werken. Samen bespreken we jouw inzetbaarheid op de afdeling. Een goede werk-privébalans vinden we belangrijk.
- Een 13e maand die we in november uitkeren en een reiskostenvergoeding.
- Een pensioenverzekering bij het ABP. Wij betalen 70% van je pensioenpremie waardoor je netto salaris hoger uitvalt dan je misschien denkt.
- Sportfaciliteiten in het Erasmus MC. En heb je een lekke band? Onze fietsenmaker repareert deze graag.
Meer informatie
For more information about this position, please contact
Martijn Schonewille
Professor
m.schonewille@erasmusmc.nl
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
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